Sodium Carbonate → 7-(2-Methyl-2H-pyrazol-3-yl)-imidazo[1,2-a]pyridine-3-carboxylic Acid {5-[2-(2,6-dimethyl-piperidin-1-yl)-ethylcarbamoyl]-2-fluoro-phenyl}-amide

HRID 335276

反応式

HRID 335276 の反応式
[F:1][C:2]1[CH:10]=[CH:9][C:5]([C:6](O)=[O:7])=[CH:4][C:3]=1[NH:11][C:12]([C:14]1[N:18]2[CH:19]=[CH:20][C:21]([C:23]3[N:24]([CH3:28])[N:25]=[CH:26][CH:27]=3)=[CH:22][C:17]2=[N:16][CH:15]=1)=[O:13].CCN=C=NCCCN(C)C.Cl.C1C=CC2N(O)N=NC=2C=1.[CH3:51][C@H:52]1[CH2:57][CH2:56][CH2:55][C@@H:54]([CH3:58])[N:53]1[CH2:59][CH2:60][NH2:61].C([O-])([O-])=O.[Na+].[Na+]>CN(C=O)C.O>[CH3:51][CH:52]1[CH2:57][CH2:56][CH2:55][CH:54]([CH3:58])[N:53]1[CH2:59][CH2:60][NH:61][C:6]([C:5]1[CH:9]=[CH:10][C:2]([F:1])=[C:3]([NH:11][C:12]([C:14]2[N:18]3[CH:19]=[CH:20][C:21]([C:23]4[N:24]([CH3:28])[N:25]=[CH:26][CH:27]=4)=[CH:22][C:17]3=[N:16][CH:15]=2)=[O:13])[CH:4]=1)=[O:7]

参加物

8

反応物 5

HCID 10340Sodium CarbonateHCID 757711-HydroxybenzotriazoleHCID 7837022-(cis-2,6-Dimethyl-1-piperidinyl)ethanamineHCID 27239391,3-Propanediamine, N'-(ethylcarbonimidoyl)-N,N-dimethyl-, monohydrochlorideHCID 712829094-fluoro-3-(7-(1-methyl-1H-pyrazol-5-yl)imidazo[1,2-a]pyridine-3-carboxamido)benzoic acid

生成物 1

HCID 780486287-(2-Methyl-2H-pyrazol-3-yl)-imidazo[1,2-a]pyridine-3-carboxylic Acid {5-[2-(2,6-dimethyl-piperidin-1-yl)-ethylcarbamoyl]-2-fluoro-phenyl}-amide

試薬・触媒・溶媒 2

HCID 962Water溶媒HCID 6228Dimethylformamide溶媒

反応条件

温度
70 °C

実験手順

4-Fluoro-3-{[7-(2-methyl-2H-pyrazol-3-yl)-imidazo[1,2-a]pyridine-3-carbonyl]-amino}-benzoic acid (step 2) (450 g, 1.19 mol), EDC.HCl (454.8 g, 2.372 mol) and HOBt (181.6 g, 1.186 mol) in DMF (3.2 L) at 25° C. were stirred for 1.5 hr. The reaction was monitored by HPLC. To the reaction mixture was dropwise added cis 2-(2,6-dimethyl-piperidin-1-yl)-ethylamine (222.5 g, 1.423 mol) over 10 min and stirring continued for 30 min. To the reaction mixture was dropwise an aqueous solution of Na2CO3 (5%, 6 L) over 120 min and the resulting solid was collected by filtration and washed with water (5 L). To the solid was added ethanol (5 L) followed by heating to 70° C. to obtain a clear solution. Water (1.5 L) was dropwise added at 70° C. and stirred for 30 min. The clear solution was slowly cooled to 25° C. over 2 hr. The solid was filtered, washed with ethanol (500 mL) and dried under vacuum at 50° C. overnight to afford the title compound as a white solid;

後処理

  1. customover 10 min
  2. customover 120 min
  3. filtrationthe resulting solid was collected by filtration
  4. washwashed with water (5 L)
  5. additionTo the solid was added ethanol (5 L)
  6. customto obtain a clear solution
  7. stirringstirred for 30 min
  8. temperatureThe clear solution was slowly cooled to 25° C. over 2 hr
  9. filtrationThe solid was filtered
  10. washwashed with ethanol (500 mL)
  11. customdried under vacuum at 50° C. overnight

出典と根拠

ORDレコード
ord-959f1227539a41438cb9d0ed6b5c4bb1
出典データセット
uspto-grants-2014_11
特許番号
US08883819B2

関連ノート

読み込み中…