4-Fluoro-2-nitrophenol → 2-Amino-4-fluorophenol

HRID 337329

反応式

HRID 337329 の反応式
[F:1][C:2]1[CH:7]=[CH:6][C:5]([OH:8])=[C:4]([N+:9]([O-])=O)[CH:3]=1>C(O)C.[Pd]>[NH2:9][C:4]1[CH:3]=[C:2]([F:1])[CH:7]=[CH:6][C:5]=1[OH:8]

参加物

4

反応物 1

HCID 1362364-Fluoro-2-nitrophenol

生成物 1

HCID 27359172-Amino-4-fluorophenol収率 86.9%

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 702Ethanol溶媒

実験手順

300 mg of 4-fluoro-2-nitrophenol was dissolved in 3 ml of ethanol, and 120 mg of 10% palladium/carbon was added and stirred under hydrogen atmosphere at room temperature for 1 hour. After the insoluble matter was filtered off, the filtrate was distilled off under reduced pressure to yield 211 mg of the title compound.

後処理

  1. filtrationAfter the insoluble matter was filtered off
  2. distillationthe filtrate was distilled off under reduced pressure

出典と根拠

ORDレコード
ord-3bdbe08535b049f4b504bdb13705ee74
出典データセット
uspto-grants-2014_11
特許番号
US08889727B2

関連ノート

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