Lawesson's reagent → (4-Isopropyl-piperazin-1-yl)-(5-piperidin-1-ylmethyl-furan-2-yl)-methanethione

HRID 33749

反応式

HRID 33749 の反応式
[CH:1]([N:4]1[CH2:9][CH2:8][N:7]([C:10]([C:12]2[O:13][C:14]([CH2:17][N:18]3[CH2:23][CH2:22][CH2:21][CH2:20][CH2:19]3)=[CH:15][CH:16]=2)=O)[CH2:6][CH2:5]1)([CH3:3])[CH3:2].COC1C=CC(P2(SP(C3C=CC(OC)=CC=3)(=S)S2)=[S:33])=CC=1>C1COCC1>[CH:1]([N:4]1[CH2:9][CH2:8][N:7]([C:10]([C:12]2[O:13][C:14]([CH2:17][N:18]3[CH2:23][CH2:22][CH2:21][CH2:20][CH2:19]3)=[CH:15][CH:16]=2)=[S:33])[CH2:6][CH2:5]1)([CH3:3])[CH3:2]

参加物

4

反応物 2

HCID 87949Lawesson's reagentHCID 11244101(4-Isopropyl-piperazin-1-yl)-(5-piperidin-1-ylmethylfuran-2-yl)-methanone

生成物 1

HCID 11508298(4-Isopropyl-piperazin-1-yl)-(5-piperidin-1-ylmethyl-furan-2-yl)-methanethione

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒

反応条件

温度
70 °C

実験手順

A solution of (4-isopropyl-piperazin-1-yl)-(5-piperidin-1-ylmethyl-furan-2-yl)-methanone (Example 1, 1 equiv.) and Lawesson's reagent (2.1 equiv.) in THF is heated at reflux (70° C.) for 48 h. The reaction is cooled to room temperature and the solvent is removed in vacuo. Chromatography of the residue on a silica gel column using 1-6% 2 M NH3 in MeOH/DCM) provides the title compound.

後処理

  1. temperatureThe reaction is cooled to room temperature
  2. customthe solvent is removed in vacuo

出典と根拠

ORDレコード
ord-1110e46f7d2f433e8f777fa8a0a330e1
出典データセット
uspto-grants-2008_09
特許番号
US07429659B2

関連ノート

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