Dimethylformamide → HCID 67062125、化合物

温度

0 °C

To a toluene solution (1 M) of 5-chloro-2-methylbenzoic acid (1 eq.) and DMF (1.2 eq.) was added at 0° C. oxalyl chloride (1.2 eq.) dropwise over 1 h. The resulting solution was stirred at 0° C. for 2 h before the volatiles were removed in vacuo. The resulting residue was taken up in dichloromethane (1 M), cooled to 0° C. and added sequentially cyclopropylamine (1.5 eq.) and Hunig's base (2 eq.) dropwise. The resulting suspension was stirred at RT for 18 h. The reaction was quenched with 1 N aq. HCl and extracted with dichloromethane. The combined organic extracts were dried over MgSO4, filtered and the filtrate concentrated in vacuo to ˜1/3 in volume. The resulting white suspension was added an equivalent volume of hexanes and the title compound was isolated via vacuum filtration.

1. customwere removed in vacuo
2. temperaturecooled to 0° C.
3. stirringThe resulting suspension was stirred at RT for 18 h
4. customThe reaction was quenched with 1 N aq. HCl
5. extractionextracted with dichloromethane
6. dry with materialThe combined organic extracts were dried over MgSO4
7. filtrationfiltered
8. concentrationthe filtrate concentrated in vacuo to ˜1/3 in volume
9. additionThe resulting white suspension was added an equivalent volume of hexanes

ORDレコード

ord-4cb72e21895442acac8909515f40dfce

出典データセット

uspto-grants-2014_11

DOI

10.6084/m9.figshare.5104873.v1

特許番号

US08889714B2