Pyrazole → 2,2-dimethyl-1-(1-methyl-1H-pyrazol-5-yl)Cyclopentanol
反応式
[NH:1]1[CH:5]=[CH:4][CH:3]=[N:2]1.[CH2:6]([Li])CCC.[CH3:11][C:12]1([CH3:18])[CH2:16][CH2:15][CH2:14][C:13]1=[O:17]>C1COCC1>[CH3:11][C:12]1([CH3:18])[CH2:16][CH2:15][CH2:14][C:13]1([C:3]1[N:2]([CH3:6])[N:1]=[CH:5][CH:4]=1)[OH:17]参加物
5
実験手順
The reaction and aftertreatment were conducted in the same manner as in Example 8a by using pyrazole (3.70 g, 45.1 mmol), n-butyl lithium (2.69 M solution in hexane; 17 mL, 45.7 mmol), 2,2-dimethylcyclopentanone (5.00 g, 44.6 mmol) and THF (100 mL), to yield the title compound (630 mg, 7.3%) as a colorless solid.
後処理
- customThe reaction and aftertreatment
出典と根拠
- ORDレコード
- ord-fd8cd709a1254c549eb6dcc43a7ba25a
- 出典データセット
- uspto-grants-2014_11
- 特許番号
- US08889741B2
反応ノート
読み込み中…