Pyrazole → HCID 79863038、化合物

HRID 337877

反応式

HRID 337877 の反応式
[NH:1]1[CH:5]=[CH:4][CH:3]=[N:2]1.[CH2:6]([Li])CCC.[CH3:11][C:12]1([CH3:18])[CH2:16][CH2:15][CH2:14][C:13]1=[O:17]>C1COCC1>[CH3:11][C:12]1([CH3:18])[CH2:16][CH2:15][CH2:14][C:13]1([C:3]1[N:2]([CH3:6])[N:1]=[CH:5][CH:4]=1)[OH:17]

参加物

5

反応物 3

HCID 1048PyrazoleHCID 1382862,2-DimethylcyclopentanoneHCID 178418339Butyllithium

生成物 1

HCID 79863038HCID 79863038、化合物収率 7.3%

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒

実験手順

The reaction and aftertreatment were conducted in the same manner as in Example 8a by using pyrazole (3.70 g, 45.1 mmol), n-butyl lithium (2.69 M solution in hexane; 17 mL, 45.7 mmol), 2,2-dimethylcyclopentanone (5.00 g, 44.6 mmol) and THF (100 mL), to yield the title compound (630 mg, 7.3%) as a colorless solid.

後処理

  1. customThe reaction and aftertreatment

出典と根拠

ORDレコード
ord-fd8cd709a1254c549eb6dcc43a7ba25a
出典データセット
uspto-grants-2014_11
特許番号
US08889741B2

関連ノート

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