3-(Trifluoromethyl)benzoyl chloride → 3-Trifluoromethyl-N-[4-(6-methoxybenzothiazol-2-yl)-phenyl]-benzamide

HRID 339520

反応式

HRID 339520 の反応式
[NH2:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[S:9][C:10]3[CH:16]=[C:15]([O:17][CH3:18])[CH:14]=[CH:13][C:11]=3[N:12]=2)=[CH:4][CH:3]=1.[F:19][C:20]([F:31])([F:30])[C:21]1[CH:22]=[C:23]([CH:27]=[CH:28][CH:29]=1)[C:24](Cl)=[O:25]>N1C=CC=CC=1>[F:19][C:20]([F:30])([F:31])[C:21]1[CH:22]=[C:23]([CH:27]=[CH:28][CH:29]=1)[C:24]([NH:1][C:2]1[CH:3]=[CH:4][C:5]([C:8]2[S:9][C:10]3[CH:16]=[C:15]([O:17][CH3:18])[CH:14]=[CH:13][C:11]=3[N:12]=2)=[CH:6][CH:7]=1)=[O:25]

参加物

4

反応物 2

HCID 752573-(Trifluoromethyl)benzoyl chlorideHCID 3918704-(6-Methoxy-1,3-benzothiazol-2-yl)aniline

生成物 1

HCID 673121363-Trifluoromethyl-N-[4-(6-methoxybenzothiazol-2-yl)-phenyl]-benzamide収率 86.3%

試薬・触媒・溶媒 1

HCID 1049Pyridine溶媒

実験手順

Prepared as described in the Amide Coupling section using 2-(4-aminophenyl)-6-methoxybenzothiazole (0.06 g, 0.23 mmol) and 3-trifluoromethylbenzoyl chloride (0.054 g, 0.26 mmol) in dry pyridine (7.5 ml) to give the title compound (0.085 g, 85%) as a colourless solid after work-up.

後処理

  1. customPrepared

出典と根拠

ORDレコード
ord-9960f492bb52472990dc749ad7477ea2
出典データセット
uspto-grants-2014_11
特許番号
US08895313B2

関連ノート

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