Pyridine → 3-Chloro-5-(trifluoromethyl)picolinaldehyde oxime

HRID 340215

反応式

HRID 340215 の反応式
[Cl:1][C:2]1[C:3]([CH:12]=O)=[N:4][CH:5]=[C:6]([C:8]([F:11])([F:10])[F:9])[CH:7]=1.Cl.[NH2:15][OH:16].N1C=CC=CC=1>C(O)C.C(OCC)(=O)C.O>[Cl:1][C:2]1[C:3]([CH:12]=[N:15][OH:16])=[N:4][CH:5]=[C:6]([C:8]([F:11])([F:10])[F:9])[CH:7]=1

参加物

7

反応物 3

HCID 1049PyridineHCID 443297Hydroxyamine hydrochlorideHCID 220187903-Chloro-5-(trifluoromethyl)picolinaldehyde

生成物 1

HCID 7182493-Chloro-5-(trifluoromethyl)picolinaldehyde oxime

試薬・触媒・溶媒 3

HCID 702Ethanol溶媒HCID 962Water溶媒HCID 8857Ethyl Acetate溶媒

実験手順

A solution of 3-chloro-5-(trifluoromethyl)picolinaldehyde (1.0 eq.), hydroxylamine hydrochloride (5.0 eq.), and pyridine (4.0 eq.) in ethanol was heated to 95° C. and stirred for 1 hour. The reaction was cooled to room temperature and diluted with ethyl acetate and water. The organic layer was washed with brine, water, dried over anhydrous MgSO4, and concentrated en vacuo to give a solid that was carried onto the next step without further purification.

後処理

  1. washThe organic layer was washed with brine, water
  2. dry with materialdried over anhydrous MgSO4
  3. concentrationconcentrated en vacuo
  4. customto give a solid
  5. customthat was carried onto the next step without further purification

出典と根拠

ORDレコード
ord-14dc081e82d34930bc4420a3d7a9cd95
出典データセット
uspto-grants-2014_11
特許番号
US08895577B2

関連ノート

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