Hydrochloric Acid → 5-Chloro-1H-pyrazolo(4,3-d)pyrimidine
反応式
[Cl:1][C:2]1[N:3]=[CH:4][C:5]2[N:10](C(=O)C)[N:9]=[CH:8][C:6]=2[N:7]=1.[OH-].[Na+].Cl>C(#N)C>[Cl:1][C:2]1[N:3]=[CH:4][C:5]2[NH:10][N:9]=[CH:8][C:6]=2[N:7]=1参加物
5
実験手順
27 mg of 1-(5-chloro-pyrazolo[4,3-d]pyrimidin-1-yl)-ethanone was dissolved in 1.5 mL of acetonitrile, added with 1.5 mL of 5N sodium hydroxide aqueous solution, and stirred for 2 hours. After adding 2N hydrochloric acid to the reaction solution to render it acidic, the solution was extracted with ethyl acetate, and the resultant organic layer was washed with saturated brine, then dried over magnesium sulfate, and the solvent was evaporated, to afford 16 mg of the title compound.
後処理
- extractionthe solution was extracted with ethyl acetate
- washthe resultant organic layer was washed with saturated brine
- dry with materialdried over magnesium sulfate
- customthe solvent was evaporated
出典と根拠
- ORDレコード
- ord-051dbe47e6fb49a4b437189075b6daeb
- 出典データセット
- uspto-grants-2008_09
- 特許番号
- US07429609B2
反応ノート
読み込み中…