Methanol → 3-(6-(4-methoxyphenyl)-9H-pyrido[2,3-b]indol-3-yl)benzenamine

HRID 341300ノート

反応式

HRID 341300 の反応式
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([C:9]2[CH:10]=[C:11]3[C:15](=[CH:16][CH:17]=2)[NH:14][C:13]2[N:18]=[CH:19][C:20]([C:22]4[CH:27]=[CH:26][CH:25]=[C:24]([N+:28]([O-])=O)[CH:23]=4)=[CH:21][C:12]3=2)=[CH:5][CH:4]=1.CO>C1COCC1.[Pd]>[CH3:1][O:2][C:3]1[CH:4]=[CH:5][C:6]([C:9]2[CH:10]=[C:11]3[C:15](=[CH:16][CH:17]=2)[NH:14][C:13]2[N:18]=[CH:19][C:20]([C:22]4[CH:23]=[C:24]([NH2:28])[CH:25]=[CH:26][CH:27]=4)=[CH:21][C:12]3=2)=[CH:7][CH:8]=1

参加物

5

反応物 2

HCID 887MethanolHCID 461841576-(4-methoxyphenyl)-3-(3-nitrophenyl)-9H-pyrido[2,3-b]indole

生成物 1

HCID 461841583-(6-(4-methoxyphenyl)-9H-pyrido[2,3-b]indol-3-yl)benzenamine収率 79%

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 8028Tetrahydrofuran溶媒

実験手順

6-(4-methoxyphenyl)-3-(3-nitrophenyl)-9H-pyrido[2,3-b]indole (35 mg, 0.09 mmol, 1 equiv.), is dissolved in anhydrous THF (1 ml), MeOH (8 ml), and palladium on charcoal (10 mg, 0.009 mmol, 0.1 equiv.), are then added in an autoclave which is flushed with argon and then pressurized with H2 (10 bar). The reaction is carried out at room temperature for 16 hours. The mixture is then filtered over Mite and washed with AcOEt. The green solid obtained is washed with methanol to afford the product as a slightly green solid (26 mg, 0.07 mmol), in 79% yield.

後処理

  1. customis flushed with argon
  2. filtrationThe mixture is then filtered over Mite
  3. washwashed with AcOEt
  4. customThe green solid obtained
  5. washis washed with methanol

出典と根拠

ORDレコード
ord-df18fe136c4e4c60a09cf37173a793e2
出典データセット
uspto-grants-2014_11
特許番号
US08895744B2

反応ノート

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