Methyl iodide → 3-Iodo-4,5-dimethoxybenzaldehyde
反応式
[I:1][C:2]1[C:3]([OH:12])=[C:4]([O:10][CH3:11])[CH:5]=[C:6]([CH:9]=1)[CH:7]=[O:8].[C:13](=O)([O-])[O-].[K+].[K+].IC>CN(C=O)C>[CH3:11][O:10][C:4]1[CH:5]=[C:6]([CH:9]=[C:2]([I:1])[C:3]=1[O:12][CH3:13])[CH:7]=[O:8]参加物
5
実験手順
A mixture of 5-iodovanillin (7 g, 25.18 mmole), potassium carbonate (8.78 g, 63.53 mmole) and iodomethane (6.43 g, 45.30 mmole) was suspended in 60 mL of DMF and stirred at room temperature for 14 hours. The reaction mixture was quenched with water and extracted with diethyl ether. The organic layer was dried over MgSO4, filtered and evaporated in vacuo to obtain a solid which was recrystallized from hexane/ethyl acetate (2:1) (6.28 g, 85.4%).
後処理
- customThe reaction mixture was quenched with water
- extractionextracted with diethyl ether
- dry with materialThe organic layer was dried over MgSO4
- filtrationfiltered
- customevaporated in vacuo
- customto obtain a solid which
- customwas recrystallized from hexane/ethyl acetate (2:1) (6.28 g, 85.4%)
出典と根拠
- ORDレコード
- ord-cf2a47a2c6ac4469ba02a0f92452f246
- 出典データセット
- uspto-grants-1999_01
- 特許番号
- US05856323
反応ノート
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