N-bromobutanimide → 2-Bromomethyl-7-nitrobenzo[b]furan

HRID 342415

反応式

HRID 342415 の反応式
[CH3:1][C:2]1[O:6][C:5]2[C:7]([N+:11]([O-:13])=[O:12])=[CH:8][CH:9]=[CH:10][C:4]=2[CH:3]=1.[Br:14]N1C(=O)CCC1=O>ClCCl.N(C(C)(CC(C)(OC)C)C#N)=NC(C)(CC(OC)(C)C)C#N>[Br:14][CH2:1][C:2]1[O:6][C:5]2[C:7]([N+:11]([O-:13])=[O:12])=[CH:8][CH:9]=[CH:10][C:4]=2[CH:3]=1

参加物

5

反応物 2

HCID 67184N-bromobutanimideHCID 132018972-Methyl-7-nitrobenzofuran

生成物 1

HCID 702014072-Bromomethyl-7-nitrobenzo[b]furan収率 85.8%

試薬・触媒・溶媒 2

HCID 858672,2'-Azobis(2,4-dimethyl-4-methoxyvaleronitrile)触媒HCID 6344Dichloromethane溶媒

実験手順

A mixture of 2-methyl-7-nitrobenzo[b]furan (2.66 g), N-bromosuccinimide (3.21 g) and 2,2'-azobis-(2,4-dimethyl-4-methoxyvaleronitrile) (270 mg) in dichloromethane (30 ml) was refluxed for 1 hour. The reaction mixture was washed with aqueous saturated sodium bicarbonate and brine, dried over sodium sulfate and concentrated in vacuo. The residue was crystallized from diethyl ether to give 2-bromomethyl-7-nitrobenzo[b]furan (3.3 g).

後処理

  1. temperaturewas refluxed for 1 hour
  2. washThe reaction mixture was washed with aqueous saturated sodium bicarbonate and brine
  3. dry with materialdried over sodium sulfate
  4. concentrationconcentrated in vacuo
  5. customThe residue was crystallized from diethyl ether

出典と根拠

ORDレコード
ord-2f69eb1bd2b8421aa4906d6bbc2b956e
出典データセット
uspto-grants-1999_01
特許番号
US05858995

関連ノート

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