Diethyl Ether → Ethyl 2-benzylideneamino-2-ethylhexanoate

HRID 342861

反応式

HRID 342861 の反応式
[H-].[Na+].[CH:3](=[N:10][CH:11]([CH2:17][CH3:18])[C:12]([O:14][CH2:15][CH3:16])=[O:13])[C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=1.[CH2:19](I)[CH2:20]CC.[Cl-].[NH4+].[CH2:26](OCC)[CH3:27]>CN(C)C=O.O>[CH:3](=[N:10][C:11]([CH2:26][CH3:27])([CH2:17][CH2:18][CH2:19][CH3:20])[C:12]([O:14][CH2:15][CH3:16])=[O:13])[C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=1

参加物

8

反応物 5

HCID 3283Diethyl EtherHCID 10962Butyl iodideHCID 24758Sodium hydrideHCID 25517Ammonium ChlorideHCID 10331026Ethyl 2-benzylideneaminobutyrate

生成物 1

HCID 10107458Ethyl 2-benzylideneamino-2-ethylhexanoate

試薬・触媒・溶媒 2

HCID 962Water溶媒HCID 6228Dimethylformamide溶媒3 回

実験手順

Sodium hydride (32.49 g, 60% dispersion in oil) and N,N-Dimethylformamide (DMF) (700 ml) were stirred under nitrogen at room temperature and a solution of the product from (b) (178.13 g) in DMF was added dropwise. After 2 hours stirring at room temperature, a solution of butyl iodide (149.48 g) in DMF was added dropwise and the reaction left stirring for a further 2 hours. The reaction was poured into an ice cold mixture of water (560 ml), diethyl ether (300 ml) and ammonium chloride (120 g). The resulting organic layer was dried over potassium carbonate then concentrated to give the desired product as a brown oil (220 g).

後処理

  1. waitthe reaction left
  2. stirringstirring for a further 2 hours
  3. dry with materialThe resulting organic layer was dried over potassium carbonate
  4. concentrationthen concentrated

出典と根拠

ORDレコード
ord-5a84ca2a8c5347bd9556224111a9eb8f
出典データセット
uspto-grants-1999_01
特許番号
US05859240

関連ノート

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