Azobisisobutyronitrile → 4-(Bromomethyl)-2-chloro-1-iodobenzene

HRID 343964ノート

反応式

HRID 343964 の反応式
[Cl:1][C:2]1[CH:3]=[C:4]([CH3:9])[CH:5]=[CH:6][C:7]=1[I:8].[Br:10]N1C(=O)CCC1=O.N(C(C)(C)C#N)=NC(C)(C)C#N>C(Cl)(Cl)(Cl)Cl>[Cl:1][C:2]1[CH:3]=[C:4]([CH:5]=[CH:6][C:7]=1[I:8])[CH2:9][Br:10]

参加物

5

反応物 3

HCID 6547AzobisisobutyronitrileHCID 67184N-bromobutanimideHCID 27576182-Chloro-1-iodo-4-methylbenzene

生成物 1

HCID 542552924-(Bromomethyl)-2-chloro-1-iodobenzene

試薬・触媒・溶媒 1

HCID 5943Carbon Tetrachloride溶媒

実験手順

A suspension of 40.4 g (160 mmol) of the compound from Example XXXI in 400 ml of carbon tetrachloride, 31.3 g of N-bromosuccinimide (176 mmol) and 2.63 g of azobisiso-butyronitrile (16 mmol) is heated under reflux overnight. After cooling, the precipitate is filtered off with suction and washed with carbon tetrachloride. The combined filtrates are concentrated and the residue is further reacted in the crude state.

後処理

  1. temperatureis heated
  2. temperatureunder reflux overnight
  3. temperatureAfter cooling
  4. filtrationthe precipitate is filtered off with suction
  5. washwashed with carbon tetrachloride
  6. concentrationThe combined filtrates are concentrated
  7. customthe residue is further reacted in the crude state

出典と根拠

ORDレコード
ord-26a5b0d63efe451aab8d09bee8e8962a
出典データセット
uspto-grants-1999_01
特許番号
US05863930

反応ノート

読み込み中…