Benzyl Chloride → Methyl(4-benzylthiophenyl)acetate

HRID 34410

反応式

HRID 34410 の反応式
[CH3:1][O:2][C:3](=[O:12])[CH2:4][C:5]1[CH:10]=[CH:9][C:8]([SH:11])=[CH:7][CH:6]=1.[CH2:13](Cl)[C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1.C([O-])([O-])=O.[K+].[K+].[OH-].[Na+]>C(O)C>[CH3:1][O:2][C:3](=[O:12])[CH2:4][C:5]1[CH:10]=[CH:9][C:8]([S:11][CH2:13][C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=2)=[CH:7][CH:6]=1

参加物

6

反応物 4

HCID 7503Benzyl ChlorideHCID 11430Potassium CarbonateHCID 14798Sodium HydroxideHCID 14033178Methyl 2-(4-mercaptophenyl)acetate

生成物 1

HCID 54174016Methyl(4-benzylthiophenyl)acetate

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

Methyl(4-mercaptophenyl)acetate (0.2 mol) is heated at reflux with benzyl chloride (25 g, 0.2 mol) and K2CO3 (25 g, 0.2 mol) in 100 mL ethanol. The product is added to aqueous NaOH, extracted with ether, and purified by silica gel chromatography to yield methyl(4-benzylthiophenyl)acetate (3). (Scheme III, Step 1.)

後処理

  1. extractionextracted with ether
  2. custompurified by silica gel chromatography

出典と根拠

ORDレコード
ord-3bd374c3ce354367ba30e6cb8a4808a1
出典データセット
uspto-grants-1988_08
特許番号
US04761420

関連ノート

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