Sodium Iodide → N-Methyl-N-(5-nitrobenzofur-2-ylmethyl)-4-nitrophenethylamine

HRID 345033

反応式

HRID 345033 の反応式
[CH3:1][NH:2][CH2:3][CH2:4][C:5]1[CH:10]=[CH:9][C:8]([N+:11]([O-:13])=[O:12])=[CH:7][CH:6]=1.Br[CH2:15][C:16]1[O:17][C:18]2[CH:24]=[CH:23][C:22]([N+:25]([O-:27])=[O:26])=[CH:21][C:19]=2[CH:20]=1.[I-].[Na+].C(=O)([O-])[O-].[K+].[K+]>C(#N)C>[CH3:1][N:2]([CH2:3][CH2:4][C:5]1[CH:10]=[CH:9][C:8]([N+:11]([O-:13])=[O:12])=[CH:7][CH:6]=1)[CH2:15][C:16]1[O:17][C:18]2[CH:24]=[CH:23][C:22]([N+:25]([O-:27])=[O:26])=[CH:21][C:19]=2[CH:20]=1

参加物

6

反応物 4

HCID 5238Sodium IodideHCID 11430Potassium CarbonateHCID 2794239N-methyl-4-nitrophenethylamineHCID 114141792-(Bromomethyl)-5-nitro-1-benzofuran

生成物 1

HCID 15735404N-Methyl-N-(5-nitrobenzofur-2-ylmethyl)-4-nitrophenethylamine

試薬・触媒・溶媒 1

HCID 6342Acetonitrile溶媒

実験手順

N-Methyl-4-nitrophenethylamine (0.41 g, 2.3 mmole), 2-bromomethyl-5-nitrobenzofuran (0.66 g, 2.6 mmole), sodium iodide (0.39 g, 2.6 mmole) and potassium carbonate (0.36 g, 2.6 mmole) were heated at reflux temperature in acetonitrile (50 ml) for 8 days. The solvent was then evaporated, water was added, and the mixture extracted three times with methylene chloride. The combined organic extracts were washed with water, dried (MgSO4) and evaporated to give a semi-solid which was recrystallised from isopropanol to give the title compound, yield 380 mg.

後処理

  1. customThe solvent was then evaporated
  2. additionwater was added
  3. extractionthe mixture extracted three times with methylene chloride
  4. washThe combined organic extracts were washed with water
  5. dry with materialdried (MgSO4)
  6. customevaporated
  7. customto give a semi-solid which
  8. customwas recrystallised from isopropanol

出典と根拠

ORDレコード
ord-5bb7939c889842d990fab3a45a06097d
出典データセット
uspto-grants-1991_10
特許番号
US05055473

関連ノート

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