Triethylamine → (3-Chloropropanoyl)urea

HRID 345170

反応式

HRID 345170 の反応式
C1C[NH:6][C:4](=[O:5])[NH:3]C1.C(N(CC)CC)C.[Cl:15][CH2:16][CH2:17][C:18](Cl)=[O:19]>C1(C)C=CC=CC=1>[Cl:15][CH2:16][CH2:17][C:18]([NH:3][C:4]([NH2:6])=[O:5])=[O:19]

参加物

5

反応物 3

HCID 8471TriethylamineHCID 693643-Chloropropionyl chlorideHCID 746152(1H)-Pyrimidinone, tetrahydro-

生成物 1

HCID 12937417(3-Chloropropanoyl)urea収率 79.8%

試薬・触媒・溶媒 1

HCID 1140Toluene溶媒

反応条件

温度
5 °C

実験手順

20.0 g of N,N'-trimethyleneurea are partially dissolved in 1000 ml of toluene under reflux and admixed with 20.2 g of triethylamine and then dropwise, in the course of 90 minutes, with a solution of 25.4 g of 3-chloropropionyl chloride. Subsequent stirring for 30 minutes, cooling down to 5° C., removal of undissolved matter by filtration and evaporating the filtrate in vacuo gives 24 g of chloropropionylurea of the formula ##STR70## as a beige powder.

後処理

  1. temperatureunder reflux
  2. customin the course of 90 minutes
  3. customremoval of undissolved matter
  4. filtrationby filtration
  5. customevaporating the filtrate in vacuo

出典と根拠

ORDレコード
ord-e25446250eeb40bdb22986ef2666127e
出典データセット
uspto-grants-1991_10
特許番号
US05055567

関連ノート

読み込み中…