Ethanol → Ethyl pyridine-4-acetate

HRID 345337

反応式

HRID 345337 の反応式
[N:1]1[CH:6]=[CH:5][C:4]([CH2:7][C:8]([OH:10])=[O:9])=[CH:3][CH:2]=1.S(=O)(=O)(O)O.[OH-].[Na+].C(=O)([O-])[O-].[Na+].[Na+].[CH2:24](O)[CH3:25]>>[N:1]1[CH:6]=[CH:5][C:4]([CH2:7][C:8]([O:10][CH2:24][CH3:25])=[O:9])=[CH:3][CH:2]=1

参加物

6

反応物 5

HCID 702EthanolHCID 1118Sulfuric AcidHCID 10340Sodium CarbonateHCID 14798Sodium HydroxideHCID 342284-Pyridineacetic acid

生成物 1

HCID 736321Ethyl pyridine-4-acetate

実験手順

A solution of 4-pyridylacetic acid in 500 ml of anhydrous ethanol containing 75 ml of concentrated sulfuric acid is refluxed 18 hours. The solution is cooled to 0° an neutralized by addition of sodium hydroxide solution and saturated aqueous sodium carbonate. Extraction with ethyl acetate yields on concentration in vacuo ethyl 4-pyridylacetate.

後処理

  1. temperatureThe solution is cooled to 0°
  2. extractionExtraction with ethyl acetate

出典と根拠

ORDレコード
ord-61150c41e72d48019cb56b347b6109b7
出典データセット
uspto-grants-1991_10
特許番号
US05057506

関連ノート

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