1-Methylcyclohexyl 2-(p-nitrophenyl)propionate → 1-Methylcyclohexyl 2-(p-aminophenyl)-propionate

HRID 34538

反応式

HRID 34538 の反応式
[N+:1]([C:4]1[CH:9]=[CH:8][C:7]([CH:10]([CH3:21])[C:11]([O:13][C:14]2([CH3:20])[CH2:19][CH2:18][CH2:17][CH2:16][CH2:15]2)=[O:12])=[CH:6][CH:5]=1)([O-])=O.[H][H]>C(O)C.[Pd]>[NH2:1][C:4]1[CH:9]=[CH:8][C:7]([CH:10]([CH3:21])[C:11]([O:13][C:14]2([CH3:20])[CH2:19][CH2:18][CH2:17][CH2:16][CH2:15]2)=[O:12])=[CH:6][CH:5]=1

参加物

5

反応物 2

HCID 540684921-Methylcyclohexyl 2-(p-nitrophenyl)propionateHCID 178418361HCID 178418361、化合物

生成物 1

HCID 137540711-Methylcyclohexyl 2-(p-aminophenyl)-propionate収率 67.1%

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 702Ethanol溶媒

実験手順

A stirred solution of 34.9 g of 1-methylcyclohexyl 2-(p-nitrophenyl)-propionate in 250 ml of absolute ethanol was hydrogenated at atmospheric pressure in the presence of 10% palladium on carbon catalyst. After the uptake of hydrogen gas was complete, the catalyst was filtered off through celite and the filtrate was evaporated to dryness. Trituration of the residue with petroleum ether gave 21.02 g (67% yield) of 1-methylcyclohexyl 2-(p-aminophenyl)-propionate as creamy white crystals melting at 85°-87° C.

後処理

  1. filtrationthe catalyst was filtered off through celite
  2. customthe filtrate was evaporated to dryness

出典と根拠

ORDレコード
ord-15fc9e5b04644708b922aada49328d83
出典データセット
uspto-grants-1988_08
特許番号
US04762840

関連ノート

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