Diethyl Malonate → diethyl (S)-2-methylbutylmalonate

HRID 345721

反応式

HRID 345721 の反応式
[Na].C[O-].[Na+].[CH3:5][C@@H:6]([CH2:9][CH3:10])[CH2:7]Br.[C:11]([O:19][CH2:20][CH3:21])(=[O:18])[CH2:12][C:13]([O:15][CH2:16][CH3:17])=[O:14]>C(O)C>[CH3:5][C@@H:6]([CH2:9][CH3:10])[CH2:7][CH:12]([C:13]([O:15][CH2:16][CH3:17])=[O:14])[C:11]([O:19][CH2:20][CH3:21])=[O:18]

参加物

6

反応物 4

HCID 7761Diethyl MalonateHCID 5360545SodiumHCID 54641671-Bromo-2-methylbutane, (+)-HCID 10942334Sodium Methoxide

生成物 1

HCID 12600622diethyl (S)-2-methylbutylmalonate

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

Sodium (57.5 g, 2.5 mols) was added to ethanol (1 l) to prepare sodium methoxide, followed by adding (S)-2-methylbutyl bromide (317 g, 2.1 mols) and diethyl malonate 400 g, 2.5 mols), refluxing the mixture for 5 hours and distilling off ethanol to obtain oily diethyl (S)-2-methylbutylmalonate.

後処理

  1. temperaturerefluxing the mixture for 5 hours
  2. distillationdistilling off ethanol

出典と根拠

ORDレコード
ord-98696a3edf844093a91efe5755259a25
出典データセット
uspto-grants-1991_10
特許番号
US05059340

関連ノート

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