Isopropanol → N4-Phenylquinazoline-4,6-diamine

HRID 346412

反応式

HRID 346412 の反応式
[C:1]1([NH:7][C:8]2[C:17]3[C:12](=[CH:13][CH:14]=[C:15]([N+:18]([O-])=O)[CH:16]=3)[N:11]=[CH:10][N:9]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.C(O)(C)C.O.NN>C(O)C.O.[Ni]>[C:1]1([NH:7][C:8]2[C:17]3[C:12](=[CH:13][CH:14]=[C:15]([NH2:18])[CH:16]=3)[N:11]=[CH:10][N:9]=2)[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1

参加物

6

反応物 3

HCID 3776IsopropanolHCID 24654Hydrazine hydrate (1:1)HCID 53281896-Nitro-N-phenylquinazolin-4-amine

生成物 1

HCID 5328187N4-Phenylquinazoline-4,6-diamine

試薬・触媒・溶媒 2

HCID 935Nickel触媒HCID 19096565Water ethanol溶媒

実験手順

A solution of 4-(phenylamino)-6-nitroquinazoline in ethanol/water and a polar solvent such as iso-propylalcohol is reacted at reflux temperature with hydrazine hydrate and Raney®Nickel. The reaction mixture is filtered, evaporated and purified by silica gel chromatography, to give the product, 4-(phenylamino)-6-aminoquinazoline.

後処理

  1. filtrationThe reaction mixture is filtered
  2. customevaporated
  3. custompurified by silica gel chromatography

出典と根拠

ORDレコード
ord-79f0fa1082b04b518e2114cf8bffea1e
出典データセット
uspto-grants-2007_02
特許番号
US07172749B2

関連ノート

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