Hydrochloric Acid → 4-Carboxy-2-carboxyethylthio-1,3-thiazole

HRID 34667

反応式

HRID 34667 の反応式
Br[CH:2]([CH3:6])[C:3]([OH:5])=[O:4].[OH-].[Na+].C([O:11][C:12]([C:14]1[N:15]=[C:16]([SH:19])[S:17][CH:18]=1)=[O:13])C.Cl>O>[C:3]([C:2]1[N:15]=[C:16]([S:17][CH2:18][CH2:14][C:12]([OH:13])=[O:11])[S:19][CH:6]=1)([OH:5])=[O:4]

参加物

6

反応物 4

HCID 313Hydrochloric AcidHCID 117292-Bromopropionic acidHCID 14798Sodium Hydroxide2 回HCID 178470113HCID 178470113、化合物

生成物 1

HCID 144152084-Carboxy-2-carboxyethylthio-1,3-thiazole

試薬・触媒・溶媒 1

HCID 962Water溶媒2 回

反応条件

温度
60 °C

実験手順

6.9 g of bromopropionic acid were dissolved in 100 ml of water, and the pH was adjusted to 7 with 1N NaOH. This solution was added dropwise to a suspension of 7.5 g of 4-ethoxycarbonyl-2-mercapto-1,3-thiazole in 75 ml of H2O. The pH was adjusted to 8-10 with 2N NaOH, and the mixture was stirred at room temperature for 4 h and at 60° C. for 2 h. The pH was maintained between 8 and 10. While cooling in ice, the mixture was acidified to pH 1 with 2N HCl, and the product was filtered off.

後処理

  1. temperatureThe pH was maintained between 8 and 10
  2. temperatureWhile cooling in ice
  3. filtrationthe product was filtered off

出典と根拠

ORDレコード
ord-437e342210694b3fa36739d83cf07047
出典データセット
uspto-grants-1988_08
特許番号
US04762848

関連ノート

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