Sodium Hydroxide → N-[5-(4-methyl-1-piperazinyl)-2-nitrophenyl]benzenesulfonamide

反応式

F[C:2]1[CH:3]=[CH:4][C:5]([N+:18]([O-:20])=[O:19])=[C:6]([NH:8][S:9]([C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=2)(=[O:11])=[O:10])[CH:7]=1.[CH3:21][N:22]1[CH2:27][CH2:26][NH:25][CH2:24][CH2:23]1.[OH-].[Na+]>>[CH3:21][N:22]1[CH2:27][CH2:26][N:25]([C:2]2[CH:3]=[CH:4][C:5]([N+:18]([O-:20])=[O:19])=[C:6]([NH:8][S:9]([C:12]3[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=3)(=[O:11])=[O:10])[CH:7]=2)[CH2:24][CH2:23]1

参加物

反応物 3

HCID 14798Sodium Hydroxide

HCID 531671-Methylpiperazine

HCID 22272573N-(5-fluoro-2-nitrophenyl)benzenesulfonamide

生成物 1

HCID 11164762N-[5-(4-methyl-1-piperazinyl)-2-nitrophenyl]benzenesulfonamide収率 78%

実験手順

N-(5-fluoro-2-nitrophenyl)benzenesulfonamide (2×0.50 g, 1.688 mmol) was treated with N-methyl-piperazine (2×4.65 g, 45.6 mmol) and put in two pyrex tubes and sealed. Each tube was put in a LabWell MW-10 microwave oven for 2 min at 50W. The reaction mixtures were combined and poured into 0.5 M NaOH (aq) and extracted with CH2Cl2, dried (MgSO4) and concentrated to give 0.99 g, (2.63 mmol) in 78% yield as a yellow solid. Anal (C17H20N4O4S) C, H, N, S; MS (posES-FIA) m/z=found: 377.4; Calcd: 376.12.