Hydrochloric Acid → Sertraline Hydrochloride

HRID 347400

反応式

HRID 347400 の反応式
[CH3:1][NH:2][C@@H:3]1[C:8]2[CH:9]=[CH:10][CH:11]=[CH:12][C:7]=2[C@H:6]([C:13]2[CH:14]=[CH:15][C:16]([Cl:20])=[C:17]([Cl:19])[CH:18]=2)[CH2:5][CH2:4]1.[ClH:21]>C(O)CC>[CH3:1][NH:2][C@@H:3]1[C:8]2[CH:9]=[CH:10][CH:11]=[CH:12][C:7]=2[C@H:6]([C:13]2[CH:14]=[CH:15][C:16]([Cl:20])=[C:17]([Cl:19])[CH:18]=2)[CH2:5][CH2:4]1.[ClH:21]

参加物

4

反応物 2

HCID 313Hydrochloric AcidHCID 68617Sertraline

生成物 1

HCID 63009Sertraline Hydrochloride収率 85%

試薬・触媒・溶媒 1

HCID 10311-Propanol溶媒2 回

実験手順

A solution of 50 g free sertraline base in 100 ml of n-propanol was added dropwise over a period of about 30 minutes at ambient temperature onto 100 ml of n-propanol containing 13 ml of 37% aqueous hydrochloric acid. About 10 minutes after the end of the addition a white crystalline solid starts to form. Stirring is maintained for 1 hour then the solid is filtered and washed. It is dried under vacuum. 47.5 g of sertraline hydrochloride form II are obtained in a 85% yield.

後処理

  1. additionAbout 10 minutes after the end of the addition a white crystalline solid starts
  2. customto form
  3. temperatureis maintained for 1 hour
  4. filtrationthe solid is filtered
  5. washwashed
  6. customIt is dried under vacuum

出典と根拠

ORDレコード
ord-da4794a09a0042efaeb2e246e4600411
出典データセット
uspto-grants-2007_02
特許番号
US07173153B2

関連ノート

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