2-(Methylthio)pyrimidin-4-amine → 4-[3-(2,2,2-Trifluoroethyl)thioureido]-2-methylthiopyrimidine
反応式
[NH2:1][C:2]1[CH:7]=[CH:6][N:5]=[C:4]([S:8][CH3:9])[N:3]=1.[F:10][C:11]([F:17])([F:16])[CH2:12][N:13]=[C:14]=[S:15]>C(#N)C>[F:10][C:11]([F:17])([F:16])[CH2:12][NH:13][C:14](=[S:15])[NH:1][C:2]1[CH:7]=[CH:6][N:5]=[C:4]([S:8][CH3:9])[N:3]=1参加物
4
実験手順
A mixture of 4-amino-2-methylthiopyrimidine (2.1 g.), 2,2,2-trifluoroethylisothiocyanate (2.8 g.) and acetonitrile (5 ml.) was stirred at 70° for 72 hours and then cooled, and the solid that crystallised was collected to give 4-[3-(2,2,2-trifluoroethyl)thioureido]-2-methylthiopyrimidine (2.15 g.) which was used without further purification.
後処理
- temperaturecooled
- customthe solid that crystallised
- customwas collected
出典と根拠
- ORDレコード
- ord-7d02c212b0174ca7822449c59ef637eb
- 出典データセット
- uspto-grants-1988_08
- 特許番号
- US04762932
反応ノート
読み込み中…