Water → HCID 21087563、化合物

HRID 348520ノート

反応式

HRID 348520 の反応式
C([O:3][C:4]([C:6]1[CH:7]=[CH:8][C:9]2[N:10]([CH2:21][CH3:22])[C:11]3[C:16]([C:17]=2[CH:18]=1)=[CH:15][C:14]([O:19][CH3:20])=[CH:13][CH:12]=3)=O)C.[H-].[Al+3].[Li+].[H-].[H-].[H-].O.[OH-].[Na+]>C1COCC1>[CH2:21]([N:10]1[C:9]2[CH:8]=[CH:7][C:6]([CH2:4][OH:3])=[CH:18][C:17]=2[C:16]2[C:11]1=[CH:12][CH:13]=[C:14]([O:19][CH3:20])[CH:15]=2)[CH3:22]

参加物

6

反応物 4

HCID 962Water2 回HCID 14798Sodium HydroxideHCID 21226445Aluminium lithium hydrideHCID 66720186HCID 66720186、化合物

生成物 1

HCID 21087563HCID 21087563、化合物収率 67.6%

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒2 回

実験手順

A solution of 9-ethyl-6-methoxycarbazole-3-carboxylic acid ethyl ester (1.36 g, 4.58 mmol) in anhydrous THF was added to a solution of lithium aluminum hydride in THF (25 mL) at 0° C. The reaction was stirred for 1 hour then water (1 mL) was added followed by 2M NaOH (1 mL) and finally water (1 mL). The reaction was then filtered on diatomaceous earth and the filtrate was dried and solvent removed in vacuo to afford 0.79 g of the crude alcohol.

後処理

  1. filtrationThe reaction was then filtered on diatomaceous earth
  2. customthe filtrate was dried
  3. customsolvent removed in vacuo

出典と根拠

ORDレコード
ord-9bc2d27146c14b3aa5e3d30abe7e164a
出典データセット
uspto-grants-2007_02
特許番号
US07176322B2

反応ノート

読み込み中…