Water → HCID 178435559、化合物

HRID 348522ノート

反応式

HRID 348522 の反応式
C([C:3]1[CH:11]=[CH:10][C:9]2[NH:8][C:7]3[CH2:12][CH2:13][CH2:14][C:6]=3[C:5]=2[CH:4]=1)#N.[H-].[Na+].[CH2:17](I)[CH3:18].O.[CH3:21][N:22](C=O)C>>[C:21]([C:10]1[C:9]2[C:5](=[C:6]3[C:14]([CH2:17][CH3:18])=[CH:13][CH:12]=[C:7]3[N:8]=2)[CH:4]=[CH:3][CH:11]=1)#[N:22]

参加物

6

反応物 5

HCID 962WaterHCID 6228DimethylformamideHCID 6340IodoethaneHCID 24758Sodium hydrideHCID 210875601,2,3,4-Tetrahydrocyclopenta[b]indole-7-carbonitrile

生成物 1

HCID 178435559HCID 178435559、化合物

実験手順

A solution of 7-cyano-1,2,3,4-tetrahydrocyclopent[b]indole (0.224 g, 1.23 mmol) in anhydrous DMF (15 mL) was cooled to 0° C. and sodium hydride (60% dispersion in mineral oil, 74 mg, 3.07 mmol) was added. The reaction was stirred for 45 minutes then ethyl iodide (0.171 g, 1.47 mmol) was added and the reaction was allowed to warm to room temperature. The mixture was stirred for 15 hours then water was added. The product precipitated and was collected by filtration, washing with little water, brine and dichloromethane to give 0.287 g of title compound.

後処理

  1. stirringThe mixture was stirred for 15 hours
  2. customThe product precipitated
  3. filtrationwas collected by filtration
  4. washwashing with little water, brine and dichloromethane

出典と根拠

ORDレコード
ord-153c6c89d1a442f7a4a8868c50c62615
出典データセット
uspto-grants-2007_02
特許番号
US07176322B2

反応ノート

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