Sodium Hydroxide → (1-methyl-1H-benzo[d]imidazol-5-yl)methanol

HRID 348525

反応式

HRID 348525 の反応式
[CH3:1][N:2]1[C:6]2[CH:7]=[CH:8][C:9]([C:11](OC)=[O:12])=[CH:10][C:5]=2[N:4]=[CH:3]1.[H-].[H-].[H-].[H-].[Li+].[Al+3].[OH-].[Na+]>C1COCC1>[OH:12][CH2:11][C:9]1[CH:8]=[CH:7][C:6]2[N:2]([CH3:1])[CH:3]=[N:4][C:5]=2[CH:10]=1

参加物

5

反応物 3

HCID 14798Sodium HydroxideHCID 965319Methyl 1-methyl-1H-benzo[d]imidazole-5-carboxylateHCID 21226445Aluminium lithium hydride

生成物 1

HCID 14518388(1-methyl-1H-benzo[d]imidazol-5-yl)methanol収率 58.6%

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒

実験手順

A solution of methyl 1-methylbenzimidazole-5-carboxylate (1.6 g, 8.42 mmol) in dry THF (80 mL) was treated with LiAlH4 (1.59 g, 42.1 mmol) and the mixture stirred for 2 hours. 1.5 mL of 5% NaOH solution was then added, and the solid which precipitated was filtered through diatomaceous earth. The filtrate was collected and the solvent removed under reduced pressure to give 0.8 g of the title compound.

後処理

  1. customthe solid which precipitated
  2. filtrationwas filtered through diatomaceous earth
  3. customThe filtrate was collected
  4. customthe solvent removed under reduced pressure

出典と根拠

ORDレコード
ord-ae711156e21b430f98d5dddcc4818b33
出典データセット
uspto-grants-2007_02
特許番号
US07176322B2

関連ノート

読み込み中…