Formaldehyde → 4,6-Dimethyl-2-(4-tolylsulfonylmethylamino)pyrimidine

HRID 34864

反応式

HRID 34864 の反応式
[NH2:1][C:2]1[N:7]=[C:6]([CH3:8])[CH:5]=[C:4]([CH3:9])[N:3]=1.[CH3:10][S:11]([OH:14])(=O)=[O:12].[C:15]1([CH3:25])[CH:20]=[CH:19]C=[C:17](S(O)(=O)=O)[CH:16]=1.[Na].[CH2:27]=O>O>[CH3:9][C:4]1[CH:5]=[C:6]([CH3:8])[N:7]=[C:2]([NH:1][CH2:27][S:11]([C:10]2[CH:19]=[CH:20][C:15]([CH3:25])=[CH:16][CH:17]=2)(=[O:14])=[O:12])[N:3]=1

参加物

7

反応物 5

HCID 712FormaldehydeHCID 6395Methanesulfonic AcidHCID 130212-Amino-4,6-dimethyl pyrimidineHCID 105362m-Toluenesulfonic acidHCID 5360545Sodium

生成物 1

HCID 230432214,6-Dimethyl-2-(4-tolylsulfonylmethylamino)pyrimidine

試薬・触媒・溶媒 1

HCID 962Water溶媒

反応条件

温度
90 °C

実験手順

12.7 g (0.1 mole) of 2-amino-4,6-dimethylpyrimidine are suspended in 200 ml of water and then 9.7 g (0.1 mole) of methanesulfonic acid are stirred in to form a solution. To the stirred solution are added, in succession, 18.22 g (0.1 mole) of toluene-3-sulfonic acid, sodium salt, and 9.4 g (0.11 mole) of aqueous 35% formaldehyde. The mixture is stirred for 2 hours at room temperature and for another 30 minutes at 90° C. The colourless precipitate is filtered with suction after cooling and dried. Melting point: 191°-194° C. Yield: 25 g (86% of theory).

後処理

  1. customto form a solution
  2. filtrationThe colourless precipitate is filtered with suction
  3. temperatureafter cooling
  4. customdried

出典と根拠

ORDレコード
ord-7d967ee7c54f4a10ad23c52de03dd4d0
出典データセット
uspto-grants-1988_08
特許番号
US04764203

関連ノート

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