Water → 3-{[(2-Methoxyethyl)(methyl)amino]methyl}-5-methylbenzoic Acid

HRID 348918

反応式

HRID 348918 の反応式
[CH3:1][O:2][CH2:3][CH2:4][N:5]([CH2:7][C:8]1[CH:9]=[C:10]([CH:15]=[C:16]([CH3:18])[CH:17]=1)[C:11]([O:13]C)=[O:12])[CH3:6].O.[OH-].[Li+]>CO.O1CCCC1>[CH3:1][O:2][CH2:3][CH2:4][N:5]([CH2:7][C:8]1[CH:9]=[C:10]([CH:15]=[C:16]([CH3:18])[CH:17]=1)[C:11]([OH:13])=[O:12])[CH3:6]

参加物

6

反応物 3

HCID 962WaterHCID 3939Lithium HydroxideHCID 21086148Methyl 3-{[(2-methoxyethyl)(methyl)amino]methyl}-5-methylbenzoate

生成物 1

HCID 210856713-{[(2-Methoxyethyl)(methyl)amino]methyl}-5-methylbenzoic Acid

試薬・触媒・溶媒 2

HCID 887Methanol溶媒HCID 8028Tetrahydrofuran溶媒

実験手順

To a stirred solution of methyl 3-{[(2-methoxyethyl)(methyl)amino]methyl}-5-methylbenzoate (180 mg, 0.72 mmol) in methanol (2 mL), tetrahydrofuran (1 mL), and water (1 mL) is added lithium hydroxide (302 mg, 7.2 mmol) and the reaction mixture stirred at room temperature for 2 h. The reaction mixture is concentrated under reduced pressure, dissolved in methylene chloride, filtered, and the filtrate concentrated under reduced pressure to provide the title compound. ESI MS m/z 238 [M+H]+.

後処理

  1. concentrationThe reaction mixture is concentrated under reduced pressure
  2. dissolutiondissolved in methylene chloride
  3. filtrationfiltered
  4. concentrationthe filtrate concentrated under reduced pressure

出典と根拠

ORDレコード
ord-28737269f39c4988859041fb350161a7
出典データセット
uspto-grants-2007_02
特許番号
US07176242B2

関連ノート

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