2,6-Dimethylaniline → N-(2,6-dimethylphenyl)-2-(4-oxo-3-thiazolidinyl)propionamide

HRID 34908

反応式

HRID 34908 の反応式
[O:1]=[C:2]1[CH2:6][S:5][CH2:4][N:3]1[CH:7]([CH3:11])[C:8]([OH:10])=O.[CH3:12][C:13]1[CH:19]=[CH:18][CH:17]=[C:16]([CH3:20])[C:14]=1[NH2:15].C1(N=C=NC2CCCCC2)CCCCC1>C(Cl)(Cl)Cl>[CH3:12][C:13]1[CH:19]=[CH:18][CH:17]=[C:16]([CH3:20])[C:14]=1[NH:15][C:8](=[O:10])[CH:7]([N:3]1[C:2](=[O:1])[CH2:6][S:5][CH2:4]1)[CH3:11]

参加物

5

反応物 3

HCID 68962,6-DimethylanilineHCID 10868DicyclohexylcarbodiimideHCID 232453502-(4-Oxo-3-thiazolidinyl)propionic acid

生成物 1

HCID 13853984N-(2,6-dimethylphenyl)-2-(4-oxo-3-thiazolidinyl)propionamide収率 45.7%

試薬・触媒・溶媒 1

HCID 6212Chloroform溶媒

実験手順

A mixture of 2-(4-oxo-3-thiazolidinyl)propionic acid (2.00 g), 2.6-dimethylaniline (1.38 g), and dicyclohexylcarbodiimide (2.35 g) in chloroform (15 ml) was refluxed for 48 hours. The resultant precipitate was removed by filtration and the filtrate was evaporated in vacuo. The residue was triturated with diethyl ether and recrystallized from ethanol to give N-(2,6-dimethylphenyl)-2-(4-oxo-3-thiazolidinyl)propionamide (1.45 g) as colorless prisms.

後処理

  1. temperaturewas refluxed for 48 hours
  2. customThe resultant precipitate was removed by filtration
  3. customthe filtrate was evaporated in vacuo
  4. customThe residue was triturated with diethyl ether
  5. customrecrystallized from ethanol

出典と根拠

ORDレコード
ord-6a9aab5ee7f74d7c9c9deececbc2446a
出典データセット
uspto-grants-1988_08
特許番号
US04764514

関連ノート

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