Hydrochloric Acid → 2-[Methyl(methylsulfonyl)amino]-1,3-oxazole-4-carboxylic acid

HRID 349126ノート

反応式

HRID 349126 の反応式
[CH3:1][N:2]([S:13]([CH3:16])(=[O:15])=[O:14])[C:3]1[O:4][CH:5]=[C:6]([C:8]([O:10]CC)=[O:9])[N:7]=1.[OH-].[Li+].O1CCCC1.Cl>O>[CH3:1][N:2]([S:13]([CH3:16])(=[O:15])=[O:14])[C:3]1[O:4][CH:5]=[C:6]([C:8]([OH:10])=[O:9])[N:7]=1

参加物

6

反応物 4

HCID 313Hydrochloric AcidHCID 3939Lithium HydroxideHCID 8028TetrahydrofuranHCID 21086092Ethyl 2-[methyl(methylsulfonyl)amino]-1,3-oxazole-4-carboxylate

生成物 1

HCID 210854712-[Methyl(methylsulfonyl)amino]-1,3-oxazole-4-carboxylic acid収率 82.4%

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

To a 50 ml round bottom flask was added (61 mg, 0.2457 mmoles) ethyl 2-[methyl(methylsulfonyl)amino]-1,3-oxazole-4-carboxylate, (51.5 mg, 1.2274 mmoles, 5.0 eq.) lithium hydroxide, (2.5 ml) tetrahydrofuran and (1.5 ml) water. The reaction was agitated at ambient temperature for ˜2 hours. The reaction was complete by electrospray mass spec. The reaction was worked up by adding (5 ml) 1N HCl and then extracting with ethyl acetate. The organic layer was washed with water and brine and then dried with magnesium sulfate. The solution was then evaporated to dryness, leaving (44.6 mg) of 2-[methyl(methylsulfonyl)amino]-1,3-oxazole-4-carboxylic acid.

後処理

  1. extractionextracting with ethyl acetate
  2. washThe organic layer was washed with water and brine
  3. dry with materialdried with magnesium sulfate
  4. customThe solution was then evaporated to dryness

出典と根拠

ORDレコード
ord-5b9baca40e22447f82347853d0190519
出典データセット
uspto-grants-2007_02
特許番号
US07176242B2

反応ノート

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