Water → HCID 3024740、化合物
反応式
Cl[CH:2]([CH3:15])[C:3]([C:5]1[CH:10]=[CH:9][C:8]([NH:11][C:12](=[O:14])[CH3:13])=[CH:7][CH:6]=1)=[O:4].Cl.[CH3:17][NH:18][CH3:19].C([O-])([O-])=O.[K+].[K+].O>CC#N>[CH3:17][N:18]([CH3:19])[CH:2]([CH3:15])[C:3]([C:5]1[CH:10]=[CH:9][C:8]([NH:11][C:12](=[O:14])[CH3:13])=[CH:7][CH:6]=1)=[O:4]参加物
6
実験手順
A mixture of N-[4-(2-chloro-1-oxopropyl)phenyl]acetamide (0.19 mol), N-methylmethanamine hydrochloride (1:1)(0.38 mol) and K2CO3 (78.8 g) in CH3CN (1400 ml) was stirred and refluxed for 12 hours. The mixture was cooled, poured into water and extracted with CH2Cl2. The organic layer was dried, filtered and the solvent was evaporated, yielding 39.77 g (89%) of (±)-N-[4-[2-(dimethylamino)-1-oxopropyl]phenyl]-acetamide (interm. 9).
後処理
- temperaturerefluxed for 12 hours
- temperatureThe mixture was cooled
- extractionextracted with CH2Cl2
- customThe organic layer was dried
- filtrationfiltered
- customthe solvent was evaporated
出典と根拠
- ORDレコード
- ord-050b4fb934c64b88a17bddd1cacbf57a
- 出典データセット
- uspto-grants-2007_02
- 特許番号
- US07179825B2
反応ノート
読み込み中…