Triethylamine → Benzamide, N-(2,3-dihydro-1H-inden-2-yl)-4-fluoro-

HRID 349584

反応式

HRID 349584 の反応式
Cl.[NH2:2][CH:3]1[CH2:11][C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH2:4]1.C(N(CC)CC)C.[F:19][C:20]1[CH:28]=[CH:27][C:23]([C:24](Cl)=[O:25])=[CH:22][CH:21]=1>O1CCCC1>[F:19][C:20]1[CH:28]=[CH:27][C:23]([C:24]([NH:2][CH:3]2[CH2:11][C:10]3[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=3)[CH2:4]2)=[O:25])=[CH:22][CH:21]=1

参加物

5

反応物 3

HCID 8471TriethylamineHCID 678794-Fluorobenzoyl chlorideHCID 1227642-Aminoindan hydrochloride

生成物 1

HCID 10131276Benzamide, N-(2,3-dihydro-1H-inden-2-yl)-4-fluoro-

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒

実験手順

43.70 g (258 mol) 2-aminoindane hydrochloride and 53.43 g (528 mmol) triethylamine were added to 250 ml of tetrahydrofuran, 42.89 g (270 mmol) 4-fluorobenzoylchloride were added, and the mixture was stirred for 2 h at RT.

後処理

  1. additionwere added

出典と根拠

ORDレコード
ord-718b7980b122441ab1ee2810010504e8
出典データセット
uspto-grants-2007_02
特許番号
US07179839B2

関連ノート

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