Hydroxyamine hydrochloride → 2-((Hydroxyimino)methyl)-5-morpholin-4-yl-phenol
反応式
[OH:1][C:2]1[CH:9]=[C:8]([N:10]2[CH2:15][CH2:14][O:13][CH2:12][CH2:11]2)[CH:7]=[CH:6][C:3]=1[CH:4]=O.Cl.[NH2:17][OH:18]>N1C=CC=CC=1>[OH:18][N:17]=[CH:4][C:3]1[CH:6]=[CH:7][C:8]([N:10]2[CH2:15][CH2:14][O:13][CH2:12][CH2:11]2)=[CH:9][C:2]=1[OH:1]参加物
4
実験手順
A solution of 2-hydroxy-4-morpholin-4-yl-ben zaldehyde (0.135 g, 0.65 mmol) in pyridine (5 mL) was treated with hydroxylamine hydrochloride (45 mg, 0.65 mmol) and stirred for 30 min at room temperature. The reaction mixture was concentrated in vacuo and the residue was partitioned between EtOAc and 5% sodium bicarbonate. The organic layer was dried over Na2SO4 and concentrated in vacuo to afford the product as a pale yellow solid (51 mg, 35%).
後処理
- concentrationThe reaction mixture was concentrated in vacuo
- customthe residue was partitioned between EtOAc and 5% sodium bicarbonate
- dry with materialThe organic layer was dried over Na2SO4
- concentrationconcentrated in vacuo
出典と根拠
- ORDレコード
- ord-2933d28a5b0046e8a6b1317020a98505
- 出典データセット
- uspto-grants-2007_02
- 特許番号
- US07179912B2
反応ノート
読み込み中…