Dichloromethane → Tert-butyl 4-[(3,4-dichlorophenyl)sulfonyl]piperidine-1-carboxylate

HRID 349745ノート

反応式

HRID 349745 の反応式
[C:1]([O:5][C:6]([N:8]1[CH2:13][CH2:12][CH:11](SC2C=CC(Cl)=C(Cl)C=2)[CH2:10][CH2:9]1)=[O:7])([CH3:4])([CH3:3])[CH3:2].[Cl:23][C:24]1[CH:29]=[CH:28][CH:27]=[C:26](C(OO)=O)[CH:25]=1.[S:34](S([O-])=O)([O-:37])(=O)=[O:35].[Na+].[Na+].[Cl:43]CCl>O>[C:1]([O:5][C:6]([N:8]1[CH2:13][CH2:12][CH:11]([S:34]([C:26]2[CH:27]=[CH:28][C:29]([Cl:43])=[C:24]([Cl:23])[CH:25]=2)(=[O:37])=[O:35])[CH2:10][CH2:9]1)=[O:7])([CH3:4])([CH3:2])[CH3:3]

参加物

6

反応物 4

HCID 6344DichloromethaneHCID 70297m-Chloroperbenzoic acidHCID 656671Sodium PyrosulfiteHCID 685523534-(3,4-Dichloro-phenylsulfanyl)-piperidine-1-carboxylic acid tert-butyl ester

生成物 1

HCID 68550800Tert-butyl 4-[(3,4-dichlorophenyl)sulfonyl]piperidine-1-carboxylate

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

The product from Step 1(1 g) and m-chloroperbenzoic acid (1.19 g) were stirred at ambient temperature in dichloromethane (10 ml) for 18 hours. Sodium metabisulphite (1.19 g) in water (5 ml) was added and stirring was continued for 0.5 hours after which the reaction mixture was extracted with dichloromethane. The combined organics were washed with saturated sodium bicarbonate solution, dried (MgSO4) and evaporated to give the sub-title compound (0.34 g).

後処理

  1. extractionafter which the reaction mixture was extracted with dichloromethane
  2. washThe combined organics were washed with saturated sodium bicarbonate solution
  3. dry with materialdried (MgSO4)
  4. customevaporated

出典と根拠

ORDレコード
ord-977f4554d94b4372bdddc62f30c3f896
出典データセット
uspto-grants-2007_02
特許番号
US07179922B2

反応ノート

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