Atropic acid → 3-[4-(Tert-butoxycarbonyl)piperazino]-2-phenylpropanoic acid

HRID 349762

反応式

HRID 349762 の反応式
[C:1]([O:5][C:6]([N:8]1[CH2:13][CH2:12][NH:11][CH2:10][CH2:9]1)=[O:7])([CH3:4])([CH3:3])[CH3:2].[C:14]1([C:20](=[CH2:24])[C:21]([OH:23])=[O:22])[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1>C(O)(C)C>[C:1]([O:5][C:6]([N:8]1[CH2:13][CH2:12][N:11]([CH2:24][CH:20]([C:21]([OH:23])=[O:22])[C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=2)[CH2:10][CH2:9]1)=[O:7])([CH3:4])([CH3:2])[CH3:3]

参加物

4

反応物 2

HCID 68114Atropic acidHCID 143452tert-Butyl piperazine-1-carboxylate

生成物 1

HCID 455884213-[4-(Tert-butoxycarbonyl)piperazino]-2-phenylpropanoic acid収率 54.3%

試薬・触媒・溶媒 1

HCID 3776Isopropanol溶媒

実験手順

Piperazine-1-carboxylic acid tert-butyl ester (17.43 g) and 2-phenylacrylic acid (18 g) in iso-propanol (500 ml) was heated at reflux for four days. The resulting precipitate was filtered, washed with diethyl ether and dried under vacuum to give the title compound as a white solid (17 g; MS: APCI+(M+H) 335).

後処理

  1. temperatureat reflux for four days
  2. filtrationThe resulting precipitate was filtered
  3. washwashed with diethyl ether
  4. customdried under vacuum

出典と根拠

ORDレコード
ord-908250ec0eec43b19824e226329ee85a
出典データセット
uspto-grants-2007_02
特許番号
US07179922B2

関連ノート

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