反応式
[F:1][C:2]1[CH:38]=[CH:37][CH:36]=[CH:35][C:3]=1[CH2:4][O:5][C:6]1[CH:7]=[C:8]2[C:13](=[CH:14][CH:15]=1)[CH:12]=[C:11]([CH2:16][N:17]1[CH:21]=[C:20]([C:22]3[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=3)[C:19]([CH2:28][CH2:29][C:30]([O:32]CC)=[O:31])=[CH:18]1)[CH:10]=[CH:9]2.[OH-].[Na+].O1CCCC1.Cl>C(O)C>[F:1][C:2]1[CH:38]=[CH:37][CH:36]=[CH:35][C:3]=1[CH2:4][O:5][C:6]1[CH:7]=[C:8]2[C:13](=[CH:14][CH:15]=1)[CH:12]=[C:11]([CH2:16][N:17]1[CH:21]=[C:20]([C:22]3[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=3)[C:19]([CH2:28][CH2:29][C:30]([OH:32])=[O:31])=[CH:18]1)[CH:10]=[CH:9]2参加物
6
反応物 4
生成物 1
試薬・触媒・溶媒 1
実験手順
A mixture of ethyl 3-[1-[6-(2-fluorobenzyloxy)-2-naphthylmethyl]-4-phenyl-3-pyrrolyl]propionate (401 mg), 1N aqueous sodium hydroxide solution (2 ml), tetrahydrofuran (4 ml) and ethanol (4 ml) was stirred at room temperature for 7 hours, and 1N hydrochloric acid (2 ml) was added to the mixture, which was extracted with ethyl acetate. The ethyl acetate layer was washed with saturated aqueous sodium chloride solution, dried (MgSO4), then concentrated. The colorless crystals obtained were collected by filtration to yield 3-[1-[6-(2-fluorobenzyloxy)-2-naphthylmethyl]-4-phenyl-3-pyrrolyl]propionic acid (289 mg, yield: 76%). This was recrystallized from ethanol-hexane. Melting point: 143–144° C.
後処理
- extractionwas extracted with ethyl acetate
- washThe ethyl acetate layer was washed with saturated aqueous sodium chloride solution
- dry with materialdried (MgSO4)
- concentrationconcentrated
- customThe colorless crystals obtained
- filtrationwere collected by filtration
出典と根拠
- ORDレコード
- ord-433cdff2a37245fdb1bae7d4b18cb610
- 出典データセット
- uspto-grants-2007_02
- 特許番号
- US07179823B1
関連ノート
読み込み中…