ホームMCPワークベンチSkills
ホームワークベンチ通知マイページ
llms.txt · MCPガイドプライバシーポリシー · 利用規約 · サポートv1.8.0
  1. ホーム
  2. /反応

Pyridine → 2-(2-Methoxyphenyl)acetamide

HRID 350835
ノート
印刷プレビュー

反応式

HRID 350835 の反応式
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=1[CH2:9][C:10]([OH:12])=O.[N:13]1C=CC=CC=1.C(OC(OC(C)(C)C)=O)(OC(C)(C)C)=O.C(=O)([O-])O.[NH4+]>C(#N)C>[CH3:1][O:2][C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=1[CH2:9][C:10]([NH2:13])=[O:12]
参加物実験手順後処理出典と根拠反応ノート

参加物

6

反応物 4

HCID 1049PyridineHCID 71342-Methoxyphenylacetic acidHCID 14013Ammonium BicarbonateHCID 90495Di-tert-butyl dicarbonate

生成物 1

HCID 806622-(2-Methoxyphenyl)acetamide

試薬・触媒・溶媒 1

HCID 6342Acetonitrile溶媒

実験手順

2-Methoxyphenylacetic acid (10.0 g, 60.1 mmol) was dissolved in acetonitrile (15 mL). Subsequently, pyridine (2.84 g, 36.1 mmol) and di-tert-butyl dicarbonate [Boc2O (19.6 g, 90.2 mmol)] were added thereto. The mixture was stirred for 10 minutes at room temperature, and then ammonium hydrogencarbonate (7.1 g, 90.2 mmol) were added. After completion of reaction, the reaction mixture was concentrated under reduced pressure. Thereafter, the resultant concentrate was added to water, and the resultant mixture was extracted with chloroform, followed by washing sequentially with 1M hydrochloric acid and brine. The resultant mixture was subjected to drying over magnesium sulfate and concentration under reduced pressure. The resultant concentrate was used in Production Example 18 without purification.

後処理

  1. customAfter completion of reaction
  2. concentrationthe reaction mixture was concentrated under reduced pressure
  3. concentrationThereafter, the resultant concentrate
  4. additionwas added to water
  5. extractionthe resultant mixture was extracted with chloroform
  6. washby washing sequentially with 1M hydrochloric acid and brine
  7. dry with materialto drying over magnesium sulfate and concentration under reduced pressure
  8. concentrationThe resultant concentrate
  9. customwas used in Production Example 18 without purification

出典と根拠

ORDレコード
ord-19e63721000f4f039d20040447f1d817
出典データセット
uspto-grants-2007_02
DOI
10.6084/m9.figshare.5104873.v1
特許番号
US07183295B2

反応ノート

読み込み中…

このページの内容参加物実験手順後処理出典と根拠反応ノート