Hydroxylamine HCl → N-hydroxy-1-(1-methyl-1H-tetrazol-5-yl)-1-phenylmethanimine

温度

45 °C

(1-methyltetrazol-5-yl)phenylmethanone (11.1 g, 59.1 mmol) and hydroxylammonium chloride (10.3 g, 148 mmol) were added to 100 ml of pyridine, followed by stirring at 45° C. for 24 hours. After the completion of the reaction, the reaction solution was concentrated under reduced pressure and water and ethyl acetate were added to the resulting residue, and then the reaction product was extracted. The organic layer was washed in turn with dilute hydrochloric acid, water and an aqueous sodium hydrogencarbonate, and the organic layer was dried over anhydrous magnesium sulfate. The solvent was distilled off from the organic layer to obtain (1-methyltetrazol-5-yl)phenylmethanoneoxime (12.0 g, yield: 100%) represented by the formua:

1. customAfter the completion of the reaction
2. concentrationthe reaction solution was concentrated under reduced pressure and water and ethyl acetate
3. additionwere added to the resulting residue
4. extractionthe reaction product was extracted
5. washThe organic layer was washed in turn with dilute hydrochloric acid, water
6. dry with materialan aqueous sodium hydrogencarbonate, and the organic layer was dried over anhydrous magnesium sulfate
7. distillationThe solvent was distilled off from the organic layer

ORDレコード

ord-ed8ca4e8b684411eb7408c665a9f1654

出典データセット

uspto-grants-2007_02

DOI

10.6084/m9.figshare.5104873.v1

特許番号

US07183299B2