Lithium Hydroxide → 2-(2,1,3-Benzoxadiazol-5-yloxy)nicotinic acid
反応式
C([O:3][C:4](=[O:21])[C:5]1[CH:10]=[CH:9][CH:8]=[N:7][C:6]=1[O:11][C:12]1[CH:20]=[CH:19][C:15]2=[N:16][O:17][N:18]=[C:14]2[CH:13]=1)C.[Li+].[OH-]>O1CCCC1>[N:16]1[O:17][N:18]=[C:14]2[CH:13]=[C:12]([O:11][C:6]3[N:7]=[CH:8][CH:9]=[CH:10][C:5]=3[C:4]([OH:21])=[O:3])[CH:20]=[CH:19][C:15]=12参加物
4
実験手順
A mixture of 2.2 g (7.7 mmol.) 2-[benzo[2,1,3]oxadiazol-5-yloxy]-nicotinic acid ethyl ester and 23.1 ml (23.1 mmol.) 1M LiOH in 75 ml tetrahydrofuran was stirred overnight at room temperature. The tetrahydrofuran was evaporated in vacuo and the aqueous mixture acidified with 1N HCl. The resulting precipitate was filtered and dried to give 1.9 g (96%) solid.
後処理
- customThe tetrahydrofuran was evaporated in vacuo
- filtrationThe resulting precipitate was filtered
- customdried
出典と根拠
- ORDレコード
- ord-b7bcdf52be5b4c27820c3fac43387305
- 出典データセット
- uspto-grants-2007_02
- 特許番号
- US07183293B2
反応ノート
読み込み中…