Sodium Hydroxide → 1152534-54-7

HRID 351242ノート

反応式

HRID 351242 の反応式
[OH-].[Na+].NC(NCCOC1C=CC([C:16]2[N:20]([C:21]3[CH:26]=[CH:25][C:24]([O:27][CH3:28])=[CH:23][CH:22]=3)[N:19]=[C:18]([C:29]([O:31]CC)=[O:30])[CH:17]=2)=CC=1)=O>C1COCC1.CO>[CH3:28][O:27][C:24]1[CH:23]=[CH:22][C:21]([N:20]2[CH:16]=[CH:17][C:18]([C:29]([OH:31])=[O:30])=[N:19]2)=[CH:26][CH:25]=1

参加物

5

反応物 2

HCID 14798Sodium HydroxideHCID 21091020HCID 21091020、化合物

生成物 1

HCID 289740221152534-54-7収率 175.6%

試薬・触媒・溶媒 2

HCID 887Methanol溶媒HCID 8028Tetrahydrofuran溶媒

実験手順

1M NaOH (5 ml) was added to a solution of ethyl 5-(4-{2-[(aminocarbonyl)amino]ethoxy}phenyl)-1-(4-methoxyphenyl)-1H-pyrazole-3-carboxylate (1.75 g) in THF (15 ml) and MeOH (10 ml). The reaction mixture was stirred at ambient temperature and concentrated in vacuo. The residue was dissolved in H2O and acidified by 1M HCl. white precipitates were collected and washed successively with H2O and IPE to give 5-(4–12-[(aminocarbonyl)amino]-ethoxy}phenyl)-1-(4-methoxyphenyl)-1H-pyrazole-3-carboxylic acid (1.58 g) as a white powder.

後処理

  1. concentrationconcentrated in vacuo
  2. dissolutionThe residue was dissolved in H2O
  3. customwhite precipitates
  4. customwere collected
  5. washwashed successively with H2O and IPE

出典と根拠

ORDレコード
ord-e9e3eccaf01242d29f5fdba52ad742b2
出典データセット
uspto-grants-2007_02
特許番号
US07183306B2

反応ノート

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