Styrene Oxide → HCID 22714722、化合物

HRID 351914ノート

反応式

HRID 351914 の反応式
[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([OH:12])=[C:6]([S:8]([OH:11])(=[O:10])=[O:9])[CH:7]=1.[Na].[OH-].[Na+].[CH2:16]1[O:24][CH:17]1[C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1>O>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([O:12][CH:17]([C:18]2[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=2)[CH2:16][OH:24])=[C:6]([S:8]([OH:11])(=[O:10])=[O:9])[CH:7]=1

参加物

6

反応物 4

HCID 7276Styrene OxideHCID 14798Sodium HydroxideHCID 5172275-chloro-2-hydroxybenzenesulfonic acidHCID 5360545Sodium

生成物 1

HCID 22714722HCID 22714722、化合物

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

A mixture of 5-chloro-2-hydroxybenzenesulfonic acid, sodium salt (7.9 g), NaOH (1.37 g) and water (25 ml) was heated on a boiling water bath until the mixture became homogeneous. Styreneoxide (2.4 g) was added dropwise over a period of 10 minutes and the mixture was heated with stirring on a boiling water bath for 1 hr. It was extracted with ether and the aqueous solution was evaporated to dryness. The residue was treated with water and the insoluble white precipitate was collected by filtration and washed with 5 mL water to obtain 2-(4-chloro-2-sulfophenoxy)-2-phenylethanol (4.1 g).

後処理

  1. temperaturewas heated on a boiling water bath until the mixture
  2. temperaturethe mixture was heated
  3. extractionIt was extracted with ether
  4. customthe aqueous solution was evaporated to dryness
  5. additionThe residue was treated with water
  6. filtrationthe insoluble white precipitate was collected by filtration
  7. washwashed with 5 mL water

出典と根拠

ORDレコード
ord-88b78f7afb8d45b7aaafed2253c9474d
出典データセット
uspto-grants-2004_06
特許番号
US06743820B2

反応ノート

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