Tetrahydrofuran → N-Benzyl-L-proline

HRID 352210ノート

反応式

HRID 352210 の反応式
C([O:3][C:4](=[O:17])[C@@H:5]1[CH2:9][CH2:8][CH2:7][N:6]1[CH2:10][C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1)C.[OH-].[Na+].O1CCCC1>CO>[CH2:10]([N:6]1[CH2:7][CH2:8][CH2:9][C@H:5]1[C:4]([OH:17])=[O:3])[C:11]1[CH:12]=[CH:13][CH:14]=[CH:15][CH:16]=1

参加物

5

反応物 3

HCID 8028TetrahydrofuranHCID 14798Sodium HydroxideHCID 688177N-Benzyl-L-proline ethyl ester

生成物 1

HCID 728719N-Benzyl-L-proline

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

N-Benzyl-L-proline ethyl ester (1.00 g, 4.3 mmol) was combined with aqueous 2N sodium hydroxide (5.0 mL, 10.0 mmol), tetrahydrofuran (2.0 mL) and MeOH (2.0 mL) and the mixture stirred at rt. until hydrolysis was complete. The mixture was then treated in a manner similar to preparation 104. Concentration of the filtrate netted 0.79 g (90%) of crude acid as a light yellowish solid. MS(ES): (M+1)+ 206.3, 207.3.

後処理

  1. customuntil hydrolysis
  2. additionThe mixture was then treated in a manner similar to preparation 104

出典と根拠

ORDレコード
ord-ad3adf203f894490af333ea0f9558871
出典データセット
uspto-grants-2004_06
特許番号
US06743794B2

反応ノート

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