Thionyl Chloride → 2-(Chloromethyl)naphthalene

HRID 352343

反応式

HRID 352343 の反応式
[CH:1]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH:4]=[CH:3][C:2]=1[CH2:11]O.S(Cl)([Cl:15])=O>C1(C)C=CC=CC=1.ClCCl>[Cl:15][CH2:11][C:2]1[CH:3]=[CH:4][C:5]2[C:10](=[CH:9][CH:8]=[CH:7][CH:6]=2)[CH:1]=1

参加物

5

反応物 2

HCID 24386Thionyl ChlorideHCID 741282-Naphthalenemethanol

生成物 1

HCID 756322-(Chloromethyl)naphthalene

試薬・触媒・溶媒 2

HCID 1140Toluene溶媒HCID 6344Dichloromethane溶媒

実験手順

To 1.26 mol of naphth-2-yl-methanol in 1.5 liters of toluene there are slowly added 3.8 mol of thionyl chloride. The mixture is then heated at reflux for two hours. After cooling, the solvent is evaporated off. The crude product is taken up in toluene twice and evaporated. The oil obtained is taken up in dichloromethane, washed and dried. After filtering and evaporating, the oil obtained is distilled to yield the expected product.

後処理

  1. temperatureThe mixture is then heated
  2. temperatureat reflux for two hours
  3. temperatureAfter cooling
  4. customthe solvent is evaporated off
  5. customevaporated
  6. customThe oil obtained
  7. washwashed
  8. customdried
  9. filtrationAfter filtering
  10. customevaporating
  11. customthe oil obtained
  12. distillationis distilled

出典と根拠

ORDレコード
ord-2b76a36fe9d8421e9983fe191e681c45
出典データセット
uspto-grants-2004_06
特許番号
US06747032B2

関連ノート

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