反応式
[Cl:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[CH:8]=[C:7]([S:12]([N:15]1[CH2:20][CH2:19][N:18]([C:21]([C:23]3[S:24][C:25]4[CH2:26][NH:27][CH:28]([CH3:32])[CH2:29][C:30]=4[N:31]=3)=[O:22])[CH:17]([C:33]([O:35]CC)=[O:34])[CH2:16]1)(=[O:14])=[O:13])[CH:6]=[CH:5]2.C(O)C.[OH-].[Na+].O>O1CCCC1>[Cl:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[CH:8]=[C:7]([S:12]([N:15]1[CH2:20][CH2:19][N:18]([C:21]([C:23]3[S:24][C:25]4[CH2:26][NH:27][CH:28]([CH3:32])[CH2:29][C:30]=4[N:31]=3)=[O:22])[CH:17]([C:33]([OH:35])=[O:34])[CH2:16]1)(=[O:14])=[O:13])[CH:6]=[CH:5]2参加物
6
反応物 4
生成物 1
試薬・触媒・溶媒 1
実験手順
In tetrahydrofuran (10 ml), 4-[(6-chloronaphthalen-2-yl)sulfonyl]-2-(ethoxycarbonyl)-1-[(6-methyl-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridin-2-yl)carbonyl]piperazine (2.08 g) was dissolved, followed by the addition of ethanol (20 ml) and a 1N aqueous solution (3.70 ml) of sodium hydroxide. The resulting mixture was stirred at room temperature for 1 hour. After concentration of the reaction mixture under reduced pressure, the residue was added with water (20 ml). The precipitate thus formed was collected by filtration, whereby the title compound (1.39 g) was obtained as a pale yellow foam.
後処理
- customThe precipitate thus formed
- filtrationwas collected by filtration, whereby the title compound (1.39 g)
- customwas obtained as a pale yellow foam
出典と根拠
- ORDレコード
- ord-90f2c4195fba489180b31f4618eb5a99
- 出典データセット
- uspto-grants-2004_06
- 特許番号
- US06747023B1
関連ノート
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