Ethanolamine → N-(2-Hydroxyethyl)pyrazine-2-carboxamide
反応式
[N:1]1[CH:6]=[CH:5][N:4]=[CH:3][C:2]=1[C:7]([O:9]C)=O.[NH2:11][CH2:12][CH2:13][OH:14]>C(OCC)(=O)C>[OH:14][CH2:13][CH2:12][NH:11][C:7]([C:2]1[CH:3]=[N:4][CH:5]=[CH:6][N:1]=1)=[O:9]参加物
4
実験手順
A mixture of 55.2 parts of methyl 2-pyrazinecarboxylate, 48.9 parts of 2-aminoethanol and 360 parts of ethyl acetate was allowed to stand overnight at room temperature. The precipitated product was filtered off, washed with ethyl acetate and dried, yielding 54.5 parts (80%) of N-(2-hydroxyethyl)-2-pyrazinecarboxamide; mp. 125° C. (intermediate 22).
後処理
- filtrationThe precipitated product was filtered off
- washwashed with ethyl acetate
- customdried
出典と根拠
- ORDレコード
- ord-5c89f624e3c24f21936bf0d2ca764d41
- 出典データセット
- uspto-grants-1988_08
- 特許番号
- US04766125
反応ノート
読み込み中…