Ethanolamine → N-(2-Hydroxyethyl)pyrazine-2-carboxamide

HRID 35313

反応式

HRID 35313 の反応式
[N:1]1[CH:6]=[CH:5][N:4]=[CH:3][C:2]=1[C:7]([O:9]C)=O.[NH2:11][CH2:12][CH2:13][OH:14]>C(OCC)(=O)C>[OH:14][CH2:13][CH2:12][NH:11][C:7]([C:2]1[CH:3]=[N:4][CH:5]=[CH:6][N:1]=1)=[O:9]

参加物

4

反応物 2

HCID 700EthanolamineHCID 72662Methyl pyrazinoate

生成物 1

HCID 14230272N-(2-Hydroxyethyl)pyrazine-2-carboxamide収率 80%

試薬・触媒・溶媒 1

HCID 8857Ethyl Acetate溶媒

実験手順

A mixture of 55.2 parts of methyl 2-pyrazinecarboxylate, 48.9 parts of 2-aminoethanol and 360 parts of ethyl acetate was allowed to stand overnight at room temperature. The precipitated product was filtered off, washed with ethyl acetate and dried, yielding 54.5 parts (80%) of N-(2-hydroxyethyl)-2-pyrazinecarboxamide; mp. 125° C. (intermediate 22).

後処理

  1. filtrationThe precipitated product was filtered off
  2. washwashed with ethyl acetate
  3. customdried

出典と根拠

ORDレコード
ord-5c89f624e3c24f21936bf0d2ca764d41
出典データセット
uspto-grants-1988_08
特許番号
US04766125

関連ノート

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