Calcium hypochlorite → HCID 22708344、化合物

HRID 353246

反応式

HRID 353246 の反応式
[Cl:1][O-].[Ca+2].Cl[O-].[F:6][C:7]([F:21])([F:20])[O:8][C:9]1[CH:10]=[CH:11][CH:12]=[C:13]2[C:18]=1[O:17][CH2:16][CH2:15][C:14]2=[O:19]>O.C(O)(=O)C.C(#N)C.O>[Cl:1][C:11]1[CH:12]=[C:13]2[C:18](=[C:9]([O:8][C:7]([F:6])([F:20])[F:21])[CH:10]=1)[O:17][CH2:16][CH2:15][C:14]2=[O:19]

参加物

6

反応物 2

HCID 24504Calcium hypochloriteHCID 22708350HCID 22708350、化合物

生成物 1

HCID 22708344HCID 22708344、化合物収率 87%

試薬・触媒・溶媒 3

HCID 962Water溶媒HCID 6342Acetonitrile溶媒HCID 21899381Acetic acid--water (1/1)溶媒

実験手順

To a solution of calcium hypochlorite (15.4 g, 72.4 mmol) in water:acetic acid (65:5) was added a solution of 8-trifluoromethoxychroman-4-one (4.2 g, 18.1 mmol; from step (iv) above) in acetonitrile (20 mL), whereafter the reaction mixture was stirred overnight. The mixture was diluted with water and extracted with ether (3 times) and EtOAc (once). The combined organic layer was washed with water, dried (Na2SO4) and evaporated, yielding 4.2 g (87%) of the sub-tide compound.

後処理

  1. extractionextracted with ether (3 times) and EtOAc (once)
  2. washThe combined organic layer was washed with water
  3. dry with materialdried (Na2SO4)
  4. customevaporated

出典と根拠

ORDレコード
ord-043020b1396d4c3b960816fe83620a9d
出典データセット
uspto-grants-2004_06
特許番号
US06750243B1

関連ノート

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