Dimethylformamide → 4-(Pyridin-4-yloxy)benzene-1-sulfonyl chloride hydrochloride

HRID 353328ノート

反応式

HRID 353328 の反応式
[N:1]1[CH:6]=[CH:5][C:4]([O:7][C:8]2[CH:13]=[CH:12][C:11]([S:14]([OH:17])(=O)=[O:15])=[CH:10][CH:9]=2)=[CH:3][CH:2]=1.CN(C=O)C.S(Cl)([Cl:25])=O>C(#N)C>[ClH:25].[N:1]1[CH:6]=[CH:5][C:4]([O:7][C:8]2[CH:13]=[CH:12][C:11]([S:14]([Cl:25])(=[O:17])=[O:15])=[CH:10][CH:9]=2)=[CH:3][CH:2]=1

参加物

5

反応物 3

HCID 6228DimethylformamideHCID 24386Thionyl ChlorideHCID 27604974-(4-Pyridinyloxy)benzenesulfonic acid

生成物 1

HCID 27352574-(Pyridin-4-yloxy)benzene-1-sulfonyl chloride hydrochloride収率 100%

試薬・触媒・溶媒 1

HCID 6342Acetonitrile溶媒

実験手順

Part C: A slurry of the sulfonic acid part B (420 g, 1.5 mol) in acetonitrile (2500 mL) and DMF (40 mL) was warmed to 75° C. under a nitrogen atmosphere and treated with thionyl chloride (243 mL, 3.3 mol) added dropwise over 3 hours. After stirring for one-half hour, the standard work-up procedure afforded 483 grams (100%) of the desired 4-[(pyrid-4-yl)oxy]benzenesulfonyl chloride hydrochloride.

後処理

  1. additionadded dropwise over 3 hours

出典と根拠

ORDレコード
ord-0f1f81267f4547be9dac4edfd506adcd
出典データセット
uspto-grants-2004_06
特許番号
US06750228B1

反応ノート

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