DL-Carnitine → Tert-butyl acetyl carnitine chloride

HRID 35371

反応式

HRID 35371 の反応式
[CH3:1][N+:2]([CH2:5][CH:6]([OH:11])[CH2:7][C:8]([O-:10])=[O:9])([CH3:4])[CH3:3].[C:12](CC([Cl:19])=O)([CH3:15])([CH3:14])[CH3:13].[CH3:20][CH2:21][O:22]CC>FC(F)(F)C(O)=O>[C:12]([CH:5]([N+:2]([CH3:3])([CH3:4])[CH3:1])[C:6]([C:21](=[O:22])[CH3:20])([CH2:7][C:8](=[O:10])[O-:9])[OH:11])([CH3:15])([CH3:14])[CH3:13].[Cl-:19]

参加物

5

反応物 3

HCID 288DL-CarnitineHCID 3283Diethyl EtherHCID 815143,3-Dimethylbutanoyl chloride

生成物 1

HCID 131715696Tert-butyl acetyl carnitine chloride収率 80%

試薬・触媒・溶媒 1

HCID 6422Trifluoroacetic acid溶媒

実験手順

Carnitine chloride (1.97 g; 0.01 moles) was dissolved in trifluoroacetic acid (10 cc). To the solution tert-butyl acetyl chloride (1.4 cc; 0.01 moles) was slowly added under stirring. The resulting mixture was kept under stirring at room temperature for 48 hours. To the mixture Et2O was added and the thus obtained precipitate was filtered off. The raw product was crystallized from isopropanol-ethyl ether, thus obtaining a pure product. MP 164°-165° C. Yield 80%

後処理

  1. stirringunder stirring at room temperature for 48 hours
  2. filtrationthe thus obtained precipitate was filtered off
  3. customThe raw product was crystallized from isopropanol-ethyl ether
  4. customthus obtaining a pure product

出典と根拠

ORDレコード
ord-02fba49a08984876a7c07be75ff83bf6
出典データセット
uspto-grants-1988_08
特許番号
US04766222

関連ノート

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