Dimethylformamide → 6-Morpholinonicotinoyl Chloride

HRID 353828

反応式

HRID 353828 の反応式
CN(C)C=O.[C:6](Cl)(=O)[C:7]([Cl:9])=[O:8].[O:12]1[CH2:17][CH2:16][N:15]([C:18]2[CH:26]=[CH:25]C(C(O)=O)=[CH:20][N:19]=2)[CH2:14][CH2:13]1>C(Cl)(Cl)Cl>[O:12]1[CH2:17][CH2:16][N:15]([C:18]2[CH:26]=[CH:25][C:6]([C:7]([Cl:9])=[O:8])=[CH:20][N:19]=2)[CH2:14][CH2:13]1

参加物

5

反応物 3

HCID 6228DimethylformamideHCID 65578Oxalyl chlorideHCID 27764606-Morpholinonicotinic Acid

生成物 1

HCID 27764616-Morpholinonicotinoyl Chloride

試薬・触媒・溶媒 1

HCID 6212Chloroform溶媒

実験手順

N,N-Dimethylformamide (1 mL) was slowly added to a solution of oxalyl chloride (0.13 g, 1 mmol) in chloroform (5 mL). 6-Morpholinonicotinic acid (0.21 g, 1 mmol) was added and the reaction mixture was stirred for 15 minutes. The reaction mixture was concentrated under vacuum, diluted with toluene and then concentrated under vacuum to provide 6-morpholinonicotinoyl chloride. This material was kept under vacuum at ambient temperature overnight and then used in the next step.

後処理

  1. concentrationThe reaction mixture was concentrated under vacuum
  2. additiondiluted with toluene
  3. concentrationconcentrated under vacuum

出典と根拠

ORDレコード
ord-ab0dabb6d4284df1a5c29527e5cd2f08
出典データセット
uspto-grants-2004_06
特許番号
US06756382B2

関連ノート

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